The Potential Effects of Scrophularia Striata Boiss on COVID-19

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) rapidly spread worldwide. The exact mechanisms involved in the pathogenesis of Coronavirus Disease 2019 (COVID-19) are not fully understood. In addition to classical treatment, herbal medicine may effectively manage COVID-19 symptoms and supportive therapy. Scrophularia striata Boiss is a perennial herbaceous plant with immunomodulatory anti-inflammatory properties. extract S. has revealed effects on reducing T helper 2 (Th2) cytokines, including IL-4 IL-5, that be used allergic diseases asthma. reduces IL-4, IL-5 alleviate ethyl acetate inhibits production IL-1β, TNF-α, PGE2. Quercetin proinflammatory mediators while increasing mediators. Ethanolic can significantly reduce NO isolated mouse peritoneal macrophages. Moreover, 3 essential flavonoids: quercetin, isorhamnetin-3-O-rutinoside, nepitrin. Of them, quercetin IL-6, PGE2, COX-2, NO, whereas increases cytokines. Therefore, recommended for clinical trial studies patients other viral diseases.